![]() Search strategies were developed by a clinical librarian at the chair's institute (AMC, Amsterdam, Netherlands) for all PICO formatted questions ( Appendix). Key questions were formulated in a PICO format (Population, Intervention, Control, Outcome) when appropriate. In the absence of RCTs a further search was performed for prospective controlled studies. In the search hierarchy the initial aim was to identify systematic meta-analysis or meta-analyses of randomized controlled trials (RCTs). Additional publications were identified by cross-reference checking of identified literature. ![]() Subsequently, for all identified questions a specific search was performed in scientific publications using electronic databases PubMed, Medline and Embase (1966–2014). Furthermore, systematic reviews were searched in the Cochrane Library and SUMsearch. As preparation for this guideline development project, a search was performed for existing guidelines from guideline institutes (, , and ) and (inter)national societies for neurologists, paediatricians and infectious disease specialists.
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